Bhattacharya D, Mittal V, Bhatia R, Sehgal S, Passey M N
National Institute of Communicable Diseases, Delhi.
J Commun Dis. 1991 Jun;23(2):144-8.
Comparative evaluation of indirect fluorescent antibody test (IFAT) and Weil-Felix test (WFT) was carried out for detecting rickettsial antibodies in 102 patients with pyrexia of unknown origin (P.U.O.), 20 brucellosis cases and 20 normal healthy controls (N.H.C.). Of 102 sera of cases with P.U.O., antibodies against rickettsia could be detected in 11 (10.7 per cent) cases by IFAT and in 10 (9.8 per cent) cases by WFT, but amongst these 10 sera, antibodies could be detected only in six by IFAT. All 20 brucella positive sera were negative for rickettsia by IFAT but by WFT in 6 sera antibodies against rickettsia could be detected and 20 N.H.C. sera were negative by both the tests. Thus the advantages of IFAT over WFT in detecting antibodies against rickettsia in terms of sensitivity and specificity make it a more reliable test.
对102例不明原因发热（PUO）患者、20例布鲁氏菌病患者和20例正常健康对照（NHC）进行了间接荧光抗体试验（IFAT）和外斐试验（WFT）检测立克次体抗体的比较评估。在102例PUO患者的血清中，通过IFAT在11例（10.7%）患者中检测到抗立克次体抗体，通过WFT在10例（9.8%）患者中检测到抗立克次体抗体，但在这10份血清中，仅通过IFAT在6例中检测到抗体。所有20份布鲁氏菌阳性血清通过IFAT检测立克次体均为阴性，但通过WFT在6份血清中检测到抗立克次体抗体，20份NHC血清两种检测均为阴性。因此，就敏感性和特异性而言，IFAT在检测抗立克次体抗体方面优于WFT，使其成为更可靠的检测方法。
