Kharal Saleem Ahmed, Hussain Qurban, Ali Shujat
Department of Microbiology, BMSI, Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan.
J Pak Med Assoc. 2009 Apr;59(4):208-12.
To determine the antibacterial properties of Quinine dihydrochloride and its MIC.
A Quasi-Experimental study was conducted at the Jinnah Postgraduate Medical Centre, Karachi from July 2006 to November 2006. Two hundred samples of pus, blood, sputum and ascitic fluid, from hospitalized adult patients from Medicine ward (W-7) having different Bacterial infections were studied. Proforma was filled to document the demographic details. Samples were collected from different sites, isolated, identified and checked for antimicrobial susceptibility of quinine dihydrochloride by standard methods.
Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa and Salmonella typhi were inhibited at MIC of 125 g/ml. Streptococcus pyogenes was inhibited at MIC of 31.25 g/ml of quinine dihydrochloride (Dilution ranges from 31.25 g/ml to 1000 g/ml).
The concomitant antimalarial and antibacterial action of Quinine dihydrochloride may be beneficial in developing countries adding to cost effectiveness of treatment provided to patients belonging to low socioeconomic group.
测定二盐酸奎宁的抗菌特性及其最低抑菌浓度（MIC）。
2006年7月至2006年11月在卡拉奇真纳研究生医学中心进行了一项准实验研究。对来自内科病房（W-7）患有不同细菌感染的成年住院患者的200份脓液、血液、痰液和腹水样本进行了研究。填写表格记录人口统计学细节。从不同部位采集样本，通过标准方法进行分离、鉴定，并检测二盐酸奎宁的抗菌敏感性。
金黄色葡萄球菌、大肠杆菌、普通变形杆菌、铜绿假单胞菌和伤寒沙门氏菌在125微克/毫升的最低抑菌浓度下受到抑制。化脓性链球菌在二盐酸奎宁最低抑菌浓度为31.25微克/毫升时受到抑制（稀释范围为31.25微克/毫升至1000微克/毫升）。
二盐酸奎宁的抗疟和抗菌协同作用可能对发展中国家有益，可提高为社会经济地位较低群体患者提供治疗的成本效益。
