Kilivnik K E, Khmarskaia L A, Ksenzhek O S
Biofizika. 2009 Mar-Apr;54(2):242-8.
The ability of weak inorganic acids (H2S, HCN) and lower carboxylic acids to interact with bilayer lipid membranes, change their conductivity, and act as protonophores has been investigated. The mechanism of changes in BLM conductivity was studied. Factors influencing the interaction of acids with model lipid membranes were determined. Maximum changes in conductivity were observed at pH values equal to the dissociation constants of weak acids and depend on the coefficients of distribution "octanol-water".
研究了弱无机酸(H2S、HCN)和低级羧酸与双层脂质膜相互作用、改变其电导率并充当质子载体的能力。研究了双层脂质膜电导率变化的机制。确定了影响酸与模型脂质膜相互作用的因素。在pH值等于弱酸解离常数时观察到最大电导率变化,且其取决于“正辛醇-水”分配系数。