[pH对胆固醇和α-月桂酸平面脂质双层性质的影响]
[Effect of pH on the properties of planar lipid bilayers of cholesterol and alpha-monolaurine].
作者信息
Bagaveev I A, Rovin Iu G, Nedozorov P M, Likhatskaia G N
出版信息
Biofizika. 1980 Nov-Dec;25(6):1091-2.
It is discovered that pH of liquid electrolyte influences the structure, stability and conductance of bilayer lipid membranes (BLM) formed from cholesterol-alpha-monolaurine mixture in n-octane. The most stable BLM are formed at cholesterol-alpha-monolaurine weight ratio 1:1, BLM specific resistance being maximal and their thickness minimal (2.9 nm). A sharp reduction of BLM stability is noted when pH is deviated in acidic or alkaline medium. The obtained data are discussed from the viewpoint of adsorbed charge influence on the structure of BLM formed of uncharged lipids.
研究发现，液体电解质的pH值会影响由胆固醇-α-月桂酸混合物在正辛烷中形成的双层脂质膜（BLM）的结构、稳定性和电导率。在胆固醇-α-月桂酸重量比为1:1时形成的BLM最稳定，其比电阻最大，厚度最小（2.9纳米）。当pH值在酸性或碱性介质中偏离时，会观察到BLM稳定性急剧下降。从吸附电荷对由不带电脂质形成的BLM结构的影响角度对所得数据进行了讨论。
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