Lyytikäinen Outi, Turunen Heli, Sund Reijo, Rasinperä Marja, Könönen Eija, Ruutu Petri, Keskimäki Ilmo
National Public Health Institute, Helsinki, Finland.
Emerg Infect Dis. 2009 May;15(5):761-5. doi: 10.3201/eid1505.081154.
To determine whether the rate of Clostridium difficile-associated disease (CDAD) and CDAD-related deaths were increasing in Finland, we analyzed registry data from 1996 through 2004. We determined the number of hospital discharges that had a diagnosis code specific for CDAD from the International Classification of Diseases, 10th revision: "enterocolitis due to Clostridium difficile" (A04.7) and "pseudomembranous enterocolitis associated with antimicrobial therapy" (K52.8), listed as any diagnosis in the National Hospital Discharge Registry. CDAD-related deaths were identified from death certificates. Those discharged with a CDAD diagnosis doubled from 810 (16/100,000 population) in 1996 to 1,787 (34/100,000) in 2004. The increase was most prominent for patients 7gt;64 years of age but concerned only those discharged with diagnosis code A04.7. The number of those discharged with diagnosis code K52.8 remained stable. The age-standardized mortality rate associated with CDAD increased from 9/million in 1998 to 17/million in 2004; the increase was limited to persons 7gt;64 years of age.
为了确定艰难梭菌相关性疾病（CDAD）的发病率及CDAD相关死亡人数在芬兰是否呈上升趋势，我们分析了1996年至2004年的登记数据。我们从国际疾病分类第10版中确定了具有CDAD特定诊断代码的医院出院人数：“艰难梭菌引起的小肠结肠炎”（A04.7）和“与抗菌治疗相关的假膜性小肠结肠炎”（K52.8），这些被列为国家医院出院登记处的任何诊断。CDAD相关死亡人数从死亡证明中确定。有CDAD诊断的出院人数从1996年的810人（每10万人中有16人）增加了一倍，至2004年的1787人（每10万人中有34人）。这种增加在64岁以上的患者中最为显著，但仅涉及那些出院诊断代码为A04.7的患者。出院诊断代码为K52.8的人数保持稳定。与CDAD相关的年龄标准化死亡率从1998年的每百万9人增加到2004年的每百万17人；这种增加仅限于64岁以上的人群。
