Wissmann Gustavo, Morilla Ruben, Friaza Vicente, Calderón Enrique, Varela Jose M
Grupo de Estudios en Pneumocystis, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil.
Enferm Infecc Microbiol Clin. 2010 Jan;28(1):38-43. doi: 10.1016/j.eimc.2008.07.008. Epub 2009 Apr 29.
Pneumocystis jirovecii, the fungal agent that causes Pneumocystis pneumonia (PCP), is known to exclusively infect humans. Molecular studies have enabled detection of this fungus in individuals who have been colonized by P. jirovecii. Such colonization, found in several populations, seems to act as a human reservoir for the fungus. Various studies have reported mutations associated with sulfa resistance in P. jirovecii strains isolated from colonized patients, who can transmit the mutant genotype to PCP-susceptible individuals. The growing interest in P. jirovecii colonization may prompt the design of new prevention and management strategies for PCP.
耶氏肺孢子菌是引起肺孢子菌肺炎（PCP）的真菌病原体，已知其仅感染人类。分子研究已能够在被耶氏肺孢子菌定植的个体中检测到这种真菌。在多个群体中发现的这种定植现象，似乎充当了该真菌的人类储存库。多项研究报告称，从定植患者分离出的耶氏肺孢子菌菌株中存在与磺胺耐药相关的突变，这些患者可将突变基因型传播给对PCP易感的个体。对耶氏肺孢子菌定植的兴趣日益浓厚，可能会促使设计出针对PCP的新预防和管理策略。
