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中国一组艾滋病患者样本中未检测到耶氏肺孢子菌二氢蝶酸合酶基因突变。

Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China.

作者信息

Li Kai, He Ai, Cai Wei Ping, Tang Xiao Ping, Zheng Xiao Ying, Li Zhuo Ya, Zhan Xi Mei

机构信息

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou510080, China.

出版信息

Scand J Infect Dis. 2009;41(2):152-4. doi: 10.1080/00365540802613087.

DOI:10.1080/00365540802613087
PMID:19085210
Abstract

Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with failure of sulfur prophylaxis of Pneumocystis pneumonia. Here the P. jirovecii DHPS gene was amplified from bronchoalveolar fluid of 10 AIDS patients in China. No DHPS gene mutations were observed. The results suggest that the prevalence of DHPS mutations in China may be low.

摘要

耶氏肺孢子菌二氢蝶酸合酶（DHPS）基因突变与肺孢子菌肺炎硫预防失败相关。在此，从中国10例艾滋病患者的支气管肺泡灌洗液中扩增出耶氏肺孢子菌DHPS基因。未观察到DHPS基因突变。结果表明，中国DHPS突变的发生率可能较低。

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