Wang Mengyan, Zhu Biao
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infection Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 May 25;46(5):563-569. doi: 10.3785/j.issn.1008-9292.2017.10.18.
pneumonia is an opportunistic infection among immunocompromised people. Studies have found that the increased resistance to sulfa drugs of may be associated with the mutation of dihydropteroate synthase () gene and dihydrofolate reductase () genes, but the mechanism is still unclear. The mutation of and genes may be the result of sulfa drugs selection or spontaneous genetic polymorphism, and it can be acquired from person-to-person transmission. This article reviews the cause, molecular epidemiology of and gene mutation, and the relationship between and gene mutation and clinical outcomes.
肺炎是免疫功能低下人群中的一种机会性感染。研究发现，[具体名称]对磺胺类药物耐药性增加可能与二氢蝶酸合酶（[具体英文名称]）基因和二氢叶酸还原酶（[具体英文名称]）基因的突变有关，但机制仍不清楚。[具体名称]和[具体名称]基因的突变可能是磺胺类药物选择或自发遗传多态性的结果，并且可通过人际传播获得。本文综述了[具体名称]和[具体名称]基因突变的原因、分子流行病学以及[具体名称]和[具体名称]基因突变与临床结局之间的关系。
