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2
Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V.尼日利亚恶性疟原虫对磺胺多辛-乙胺嘧啶耐药性的分子决定因素及二氢蝶酸合酶431V在该地区的出现
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Diagn Microbiol Infect Dis. 2017 Jan;87(1):32-36. doi: 10.1016/j.diagmicrobio.2016.10.005. Epub 2016 Oct 7.
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[关于……中与磺胺类药物耐药相关基因突变的研究进展] 你提供的原文不完整，句末括号里应该还有具体内容。

[Research progress on genes mutations related to sulfa drug resistance in ].

作者信息

Wang Mengyan, Zhu Biao

机构信息

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infection Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 May 25;46(5):563-569. doi: 10.3785/j.issn.1008-9292.2017.10.18.

DOI:10.3785/j.issn.1008-9292.2017.10.18
PMID:29488726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10397033/
Abstract

pneumonia is an opportunistic infection among immunocompromised people. Studies have found that the increased resistance to sulfa drugs of may be associated with the mutation of dihydropteroate synthase () gene and dihydrofolate reductase () genes, but the mechanism is still unclear. The mutation of and genes may be the result of sulfa drugs selection or spontaneous genetic polymorphism, and it can be acquired from person-to-person transmission. This article reviews the cause, molecular epidemiology of and gene mutation, and the relationship between and gene mutation and clinical outcomes.

摘要

肺炎是免疫功能低下人群中的一种机会性感染。研究发现，[具体名称]对磺胺类药物耐药性增加可能与二氢蝶酸合酶（[具体英文名称]）基因和二氢叶酸还原酶（[具体英文名称]）基因的突变有关，但机制仍不清楚。[具体名称]和[具体名称]基因的突变可能是磺胺类药物选择或自发遗传多态性的结果，并且可通过人际传播获得。本文综述了[具体名称]和[具体名称]基因突变的原因、分子流行病学以及[具体名称]和[具体名称]基因突变与临床结局之间的关系。