二硫化碳暴露会减弱大鼠的肾上腺素能变力反应。
Carbon disulfide exposure attenuates adrenergic inotropic response in rats.
作者信息
Klapperstück M, Müller S, Hoffmann P
机构信息
Institute of Industrial Toxicology, Martin-Luther-University, Halle, Saale BRD.
出版信息
J Hyg Epidemiol Microbiol Immunol. 1991;35(2):113-20.
Catecholamine-induced myocardial necrosis is enhanced in carbon disulfide exposed rats. We investigated whether the reported morphological findings after carbon disulfide exposure are accompanied by functional disturbances of the adrenergic inotropic response as well as by biochemical alterations. The cardiac effects of epinephrine and norepinephrine were studied in urethane-anesthetized rats which had been subacutely exposed to carbon disulfide. Compared with not exposed control animals left ventricular inotropic response was diminished and the transient T-wave elevation of the ECG due to ischemic episodes was enhanced in carbon disulfide-exposed rats. Activity of LDH-isozymes in the myocardium was shifted toward LDH-M. Our results support the hypothesis that carbon disulfide causes disturbances of energy supply in the heart.
在二硫化碳暴露的大鼠中，儿茶酚胺诱导的心肌坏死会增强。我们研究了二硫化碳暴露后报告的形态学发现是否伴有肾上腺素能变力反应的功能障碍以及生化改变。在亚急性暴露于二硫化碳的乌拉坦麻醉大鼠中研究了肾上腺素和去甲肾上腺素对心脏的影响。与未暴露的对照动物相比，二硫化碳暴露大鼠的左心室变力反应减弱，并且由于缺血发作导致的心电图短暂T波升高增强。心肌中乳酸脱氢酶同工酶的活性向乳酸脱氢酶-M转移。我们的结果支持二硫化碳会导致心脏能量供应紊乱这一假说。
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