Hoffmann P, Müller S
Institute of Industrial Toxicology, Martin Luther University, Halle, GDR.
Biomed Biochim Acta. 1990;49(1):115-20.
The influence of subacute carbon disulfide exposure (1.66 or 3.32 mmol/kg) on cardiovascular actions of epinephrine (1 or 4 micrograms/kg iv) and norepinephrine (2 or 10 micrograms/kg iv) was investigated in the urethane-anesthetized rat model. Hypertensive adrenergic effects were enhanced and inotropic effects were diminished in carbon disulfide exposed rats. Atrioventricular impulse conduction was delayed after carbon disulfide exposure, and we observed an increased number of extrasystoles in these animals. Transient T-wave elevation after catecholamine injection was augmented in carbon disulfide exposed rats. Our results demonstrate that subacute carbon disulfide exposure modifies adrenergic cardiovascular actions in rats.
在乌拉坦麻醉的大鼠模型中，研究了亚急性二硫化碳暴露（1.66或3.32 mmol/kg）对肾上腺素（静脉注射1或4微克/千克）和去甲肾上腺素（静脉注射2或10微克/千克）心血管作用的影响。在暴露于二硫化碳的大鼠中，高血压性肾上腺素能作用增强，而变力作用减弱。二硫化碳暴露后房室冲动传导延迟，并且我们观察到这些动物的早搏数量增加。在暴露于二硫化碳的大鼠中，儿茶酚胺注射后的短暂T波抬高增强。我们的结果表明，亚急性二硫化碳暴露会改变大鼠的肾上腺素能心血管作用。
