Cooper P J
Laboratorio de Investigaciones FEPIS, Quinindé, Esmeraldas Province, Ecuador.
Mucosal Immunol. 2009 Jul;2(4):288-99. doi: 10.1038/mi.2009.14. Epub 2009 Apr 29.
There is limited data on the human mucosal immune response to geohelminths, but extensive data from experimental animals. Geohelminth infections may modulate mucosal immunity with effects on parasite expulsion or persistence and mucosal inflammation. Geohelminths are considered to have important effects on immunity to mucosal vaccines, infectious disease susceptibility, and anti-inflammatory effects in inflammatory bowel disease and asthma. This review will discuss the findings of studies of human immunity to geohelminths and their potential effects on non-parasite mucosal immune responses. Such effects are likely to be of public health importance in middle- and low-income countries where these parasites are endemic. There is a need for human studies on the effects of geohelminth infections on mucosal immunity and the potential for anthelmintic treatment to modify these effects. Such studies are likely to provide important insights into the regulation of mucosal immunity and inflammation, and the development of more effective mucosal vaccines.
关于人体对土源性蠕虫的黏膜免疫反应的数据有限，但有来自实验动物的大量数据。土源性蠕虫感染可能调节黏膜免疫，对寄生虫的排出或持续存在以及黏膜炎症产生影响。土源性蠕虫被认为对黏膜疫苗免疫、传染病易感性以及炎症性肠病和哮喘中的抗炎作用具有重要影响。本综述将讨论人体对土源性蠕虫免疫的研究结果及其对非寄生虫黏膜免疫反应的潜在影响。在这些寄生虫为地方病的中低收入国家，此类影响可能具有重要的公共卫生意义。有必要开展关于土源性蠕虫感染对黏膜免疫的影响以及驱虫治疗改变这些影响的可能性的人体研究。此类研究可能为黏膜免疫和炎症的调节以及更有效的黏膜疫苗的开发提供重要见解。
