Centro de Investigaciónes FEPIS, Esmeraldas Quinindé, Ecuador.
J Trop Med. 2012;2012:132583. doi: 10.1155/2012/132583. Epub 2012 Jan 11.
Immune responses to oral vaccines are impaired in populations living in conditions of poverty in developing countries, and there is evidence that concurrent geohelminth infections may contribute to this effect. We vaccinated 48 children living in rural communities in Ecuador with a single oral dose of 100 mg of BCG Moreau RDJ and measured the frequencies of tuberculin-stimulated peripheral blood mononuclear cells expressing IFN-γ before and after vaccination. Vaccinated children had active ascariasis (n = 20) or had been infected but received short- (n = 13) or long-term (n = 15) repeated treatments with albendazole prior to vaccination to treat ascariasis. All children had a BCG scar from neonatal vaccination. There was no evidence of a boosting of postvaccination IFN-γ responses in any of the 3 study groups. Our data provide support for the presence of a barrier to oral vaccination among children from the rural tropics that appeared to be independent of concurrent ascariasis.
发展中国家贫困地区的人群对口服疫苗的免疫反应受损，有证据表明同时存在的土源性蠕虫感染可能对此有影响。我们给居住在厄瓜多尔农村社区的 48 名儿童接种了 100mg 的卡介苗 Moreau RDJ，并用结核菌素刺激外周血单核细胞来测量接种前后 IFN-γ 的表达频率。接种疫苗的儿童患有活动性蛔虫病（n=20），或者在接种前因蛔虫病接受了短期（n=13）或长期（n=15）重复的阿苯达唑治疗。所有儿童都有新生儿接种卡介苗后的疤痕。在 3 个研究组中，均没有证据表明接种后 IFN-γ 反应有增强。我们的数据为农村热带地区儿童口服疫苗接种存在障碍提供了支持，这种障碍似乎与同时存在的蛔虫病无关。
