Testa Roberto, Bonfigli Anna Rita, Prattichizzo Francesco, La Sala Lucia, De Nigris Valeria, Ceriello Antonio
Experimental Models in Clinical Pathology, INRCA-IRCCS National Institute, Ancona I-60127, Italy.
Scientific Direction, INRCA-IRCCS National Institute, Ancona I-60127, Italy.
Nutrients. 2017 Apr 28;9(5):437. doi: 10.3390/nu9050437.
Several epidemiological and prospective studies suggest that an early intensive control of hyperglycaemia is able to decrease the risk of diabetic micro- and macro-vascular complications. A growing body of experimental evidence supports the concept that the risk for diabetes complications may be linked to oxidative stress, non-enzymatic glycation of proteins, epigenetic changes, and chronic inflammation, laying the foundation for the "metabolic memory" theory. From a clinical point of view, this theory supports the need for a very early aggressive treatment, with the goal of normalizing metabolic control as soon as possible. It may also prove beneficial to introduce therapeutic agents that are able to reduce reactive species and glycation, in addition to presenting better control of glucose levels in patients with diabetes, in order to minimize long-term diabetes complications. In this review, we evaluate the effect of glucose intake and metabolism in the light of this theory.
多项流行病学和前瞻性研究表明，早期强化控制高血糖能够降低糖尿病微血管和大血管并发症的风险。越来越多的实验证据支持这样一种观点，即糖尿病并发症的风险可能与氧化应激、蛋白质的非酶糖基化、表观遗传变化和慢性炎症有关，这为“代谢记忆”理论奠定了基础。从临床角度来看，该理论支持尽早进行积极治疗，目标是尽快使代谢控制正常化。除了更好地控制糖尿病患者的血糖水平外，引入能够减少活性物质和糖基化的治疗药物可能也被证明是有益的，以便将糖尿病长期并发症降至最低。在本综述中，我们根据这一理论评估葡萄糖摄入和代谢的影响。
