Gutsmiedl Katrin, Wirges Christian T, Ehmke Veronika, Carell Thomas
Center for Integrative Protein Science at the Department of Chemistry and Biochemistry, Ludwig Maximilians University, Butenandtstr 5-13, 81377 Munich.
Org Lett. 2009 Jun 4;11(11):2405-8. doi: 10.1021/ol9005322.
Nitrile oxides react smoothly and rapidly with norbornene-modified DNA in a copper-free click reaction. The reaction allows high density functionalization of oligodeoxyribonucleotides (ODNs) with a large variety of molecules directly on solid supports and even in synthesizers without the need for an additional catalyst.
腈氧化物在无铜点击反应中能与降冰片烯修饰的DNA顺利且快速地发生反应。该反应能够在无需额外催化剂的情况下，直接在固体支持物上甚至在合成仪中，用多种分子对寡脱氧核糖核苷酸（ODN）进行高密度功能化修饰。
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