固相应变促进通过 [3+2]-氮氧化物-环辛炔环加成反应对 DNA 进行“点击”修饰。
Solid phase strain promoted "click" modification of DNA via [3+2]-nitrile oxide-cyclooctyne cycloadditions.
机构信息
Department of Chemistry, National University of Ireland, Maynooth, Co. Kildare, Republic of Ireland.
出版信息
Chem Commun (Camb). 2011 Mar 7;47(9):2706-8. doi: 10.1039/c0cc03985c. Epub 2010 Dec 21.
PMID:21173984
Abstract
Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctyne-nitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.
摘要
报道了一种快速、无催化剂的固相 DNA 修饰方法，即应变促进的环辛炔-氮氧化物点击化学；该反应具有条件温和的特点，在大气条件下于水相环境中、在室温下进行，10 分钟即可完成。
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