反射模式下采用环形光照明的超声调制光学层析成像
Ultrasound-modulated optical tomography in reflection mode with ring-shaped light illumination.
作者信息
Kim Chulhong, Song Kwang Hyun, Maslov Konstantin, Wang Lihong V
机构信息
Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
出版信息
J Biomed Opt. 2009 Mar-Apr;14(2):024015. doi: 10.1117/1.3088224.
We have succeeded in implementing ring-shaped light illumination ultrasound-modulated optical tomography (UOT) in reflection mode. The system used intense acoustic bursts and a charge-coupled device (CCD) camera-based speckle contrast detection method. In addition, the implementation allows placing the tissue sample below (not within) an acoustic coupling water tank and scanning the tissue without moving the sample. Thus, the UOT system is more clinically applicable than previous transmission-mode systems. Furthermore, we have successfully imaged an ex vivo methylene-blue-dyed sentinel lymph node (SLN) embedded at a depth of 13 mm in chicken breast tissue. This UOT system offers several advantages: noninvasiveness, nonionizing radiation, portability, cost effectiveness, and the possibility of combination with ultrasound pulse-echo imaging and photoacoustic imaging. One potential application of the UOT system is mapping SLNs in axillary staging for breast cancer patients.
我们成功地实现了反射模式下的环形光照明超声调制光学断层扫描（UOT）。该系统使用高强度声脉冲和基于电荷耦合器件（CCD）相机的散斑对比度检测方法。此外，这种实现方式允许将组织样本放置在声学耦合水箱下方（而非内部），并且在不移动样本的情况下对组织进行扫描。因此，与之前的透射模式系统相比，该UOT系统在临床上更具适用性。此外，我们成功地对埋植于鸡胸组织中深度为13毫米的离体亚甲蓝染色前哨淋巴结（SLN）进行了成像。这种UOT系统具有多个优点：非侵入性、非电离辐射、便携性、成本效益以及与超声脉冲回波成像和光声成像相结合的可能性。UOT系统的一个潜在应用是在乳腺癌患者腋窝分期中对前哨淋巴结进行定位。
Zotero 插件