Univ. of Twente, Netherlands.
J Biomed Opt. 2021 Sep;26(9). doi: 10.1117/1.JBO.26.9.096001.
Performance of an acousto-optic imaging system is limited by light fluence rate and acoustic pressure field distributions characteristics. In optically scattering media, the former determines the achievable contrast, whereas the latter the imaging resolution. The system parameters can be shaped by changing relative positions of ultrasound (US) transducer array and optodes. However, in the case of many potential clinical applications, optimization possibilities in this regard are limited, as a sample is accessible from one side only and using a water tank for coupling is not feasible.
We investigate the possibilities of improving performance of an acousto-optic imaging system operating in reflection mode geometry with linear US array in direct contact with a sample using plane wave instead of focused US pulses.
Differences in acoustic pressure field distributions for various transducer excitation patterns were determined numerically and experimentally. Acousto-optic images of phantoms with and without optically absorbing inclusions were acquired by measuring laser speckle contrast decrease due to the light modulation by plane wave and focused US pulses with different apodization patterns.
The residual acoustic pressure field components occupy relatively large volume and contribute to light modulation. Using nonsteered plane wave US pulses instead of focused ones allows one to mitigate their influence. It also allows one to obtain clear two-dimensional reconstructions of light fluence rate maps by shifting transducer apodization along the lateral direction.
Using nonsteered plane wave US pulses allows one to achieve better imaging performance than with focused pulses in the assumed system geometry.
声光成像系统的性能受到光通量率和声波压力场分布特性的限制。在光散射介质中,前者决定了可实现的对比度,而后者决定了成像分辨率。通过改变超声(US)换能器阵列和光学位的相对位置,可以改变系统参数。然而,在许多潜在的临床应用中,在这方面的优化可能性是有限的,因为只能从一侧访问样品,并且使用水箱进行耦合是不可行的。
我们研究了在与样品直接接触的线性 US 阵列的反射模式几何形状中,使用平面波而不是聚焦 US 脉冲来改善声光成像系统性能的可能性。
数值和实验确定了各种换能器激励模式的声压场分布差异。通过测量由于光调制引起的激光散斑对比度降低,获得了具有和不具有光学吸收体的体模的声光图像,调制由平面波和具有不同变迹模式的聚焦 US 脉冲引起。
残余声压场分量占据相对较大的体积,并对光调制有贡献。使用非定向平面波 US 脉冲代替聚焦脉冲可以减轻它们的影响。它还允许通过沿横向方向移动换能器变迹来获得光通量率图的清晰二维重建。
在假设的系统几何形状中,使用非定向平面波 US 脉冲可以比使用聚焦脉冲获得更好的成像性能。