Dipartimento di Neuroscienze, Sezione di Fisiologia, Università di Parma, Istituto Italiano di Tecnologia, Unità di Parma, Parma, Italy.
Cereb Cortex. 2010 Jan;20(1):141-68. doi: 10.1093/cercor/bhp087.
We have found that the 2 architectonic subdivisions of the prefrontal area 45, 45A and 45B, display connectivity patterns that clearly distinguish them from one another and from their neighboring architectonic areas. Area 45A is primarily connected to the frontal areas 45B, 12l, caudal 12r, 12o, 10, rostrodorsal 46, 9/8B, 44, 8/FEF (frontal eye field), and the SEF (supplementary eye field), temporal area IPa, and unique among all the studied areas, to the superior temporal polysensory (STP) area and auditory parabelt areas. Area 45B displayed much stronger frontal connections with the oculomotor areas 8/FEF, 8r, and the SEF than those of area 45A, primary connections with areas 12l, caudal 12r, 12o, and 8B, and unlike area 45A, with areas ventrorostral 46, rostral 12r, 12m, and 13m. Temporal connections were all virtually confined to areas IPa, intermediate TEa/m, and TE. Additional labeling was found in lateral intraparietal area. Our data suggest that 45A and 45B are 2 distinct areas, possibly playing a differential role in nonspatial information processing: area 45A corresponds to the prefrontal sector for which a role in communication behavior and homology with the human area 45 was proposed, whereas area 45B is a distinct prearcuate area, possibly affiliated to the oculomotor frontal system.
我们发现，前额区域 45、45A 和 45B 的这两个结构细分区域具有明显不同的连接模式，可以将它们彼此区分开来，并与它们相邻的结构区域区分开来。区域 45A 主要与前额区域 45B、12l、尾侧 12r、12o、10、背侧 46、9/8B、44、8/FEF（额眼区）和 SEF（补充眼区）、颞叶 IPa 区以及所有研究区域中唯一的上颞多感觉（STP）区和听觉副听区相连。与区域 45A 相比，区域 45B 与动眼区 8/FEF、8r 和 SEF 的连接更为紧密，与 12l、尾侧 12r、12o 和 8B 的连接更为初级，与腹侧 46、背侧 12r、12m 和 13m 的连接则不同。颞叶连接几乎完全局限于 IPa、中间 TEa/m 和 TE 区。还在侧顶内区发现了其他标记。我们的数据表明，45A 和 45B 是两个不同的区域，可能在非空间信息处理中发挥不同的作用：区域 45A 对应于被提议在通讯行为中发挥作用且与人类区域 45 同源的前额区域，而区域 45B 则是一个独特的前弓状区域，可能与动眼额叶系统有关。
