Suvanapha R, Tungsanga K, Laorpatanaskul S, Sitprija V, Suwan S
Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 1991 Apr;74(4):211-7.
The effect of chronic renal failure (CRF) on the pattern of plasma free amino acid concentrations was studied in 22 healthy controls (group 1); 43 CRF patients of which serum creatinine levels were 2-4.9 mg/dl (group 2, n = 11), 5-10 mg/dl (group 3, n = 10), more than 10 mg/dl (group 4, n = 9), and chronically hemodialysed patients (group 5, n = 13). In all renal failure groups, plasma concentrations of eight free essential amino acids-isoleucine, leucine, lysine, methionine, threonine, tryptophan, tyrosine and valine and those of three non-essential amino acids-alanine, glutamate and serine were significantly lower than those in controls. Plasma concentrations of free arginine, cystine, glutamate and serine were significantly higher in CRF patients. Patterns of change of plasma aminogram were similar among CRF patients regardless of the stages of renal function or dialytic treatment. Stepwise changes of some plasma free amino acids were observed as renal function became worse. The molar ratios of plasma free valine/glycine, serine/glycine and tyrosine/phenylalanine were decreased accordingly. Our study confirms the presence of abnormal plasma aminogram, specifically that of essential amino acids, in CRF. Therapeutic intervention is warranted but still needs further investigations.
研究了慢性肾衰竭（CRF）对血浆游离氨基酸浓度模式的影响，研究对象包括22名健康对照者（第1组）；43名CRF患者，其中血清肌酐水平为2 - 4.9mg/dl（第2组，n = 11）、5 - 10mg/dl（第3组，n = 10）、超过10mg/dl（第4组，n = 9），以及长期接受血液透析的患者（第5组，n = 13）。在所有肾衰竭组中，8种游离必需氨基酸（异亮氨酸、亮氨酸、赖氨酸、蛋氨酸、苏氨酸、色氨酸、酪氨酸和缬氨酸）以及3种非必需氨基酸（丙氨酸、谷氨酸和丝氨酸）的血浆浓度均显著低于对照组。CRF患者血浆中游离精氨酸、胱氨酸、谷氨酸和丝氨酸的浓度显著升高。无论肾功能阶段或透析治疗情况如何，CRF患者血浆氨基酸谱的变化模式相似。随着肾功能变差，观察到一些血浆游离氨基酸的逐步变化。血浆游离缬氨酸/甘氨酸、丝氨酸/甘氨酸和酪氨酸/苯丙氨酸的摩尔比相应降低。我们的研究证实了CRF患者存在异常的血浆氨基酸谱，特别是必需氨基酸的异常。有必要进行治疗干预，但仍需进一步研究。
