Arnold Alice M, Newman Anne B, Dermond Norma, Haan Mary, Fitzpatrick Annette
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Neuroepidemiology. 2009;33(1):55-65. doi: 10.1159/000215830. Epub 2009 Apr 28.
To estimate an equivalent to the Modified Mini-Mental State Exam (3MSE), and to compare changes in the 3MSE with and without the estimated scores.
Comparability study on a subset of 405 participants, aged >or=70 years, from the Cardiovascular Health Study (CHS), a longitudinal study in 4 United States communities. The 3MSE, the Telephone Interview for Cognitive Status (TICS) and the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) were administered within 30 days of one another. Regression models were developed to predict the 3MSE score from the TICS and/or IQCODE, and the predicted values were used to estimate missing 3MSE scores in longitudinal follow-up of 4,274 CHS participants.
The TICS explained 67% of the variability in 3MSE scores, with a correlation of 0.82 between predicted and observed scores. The IQCODE alone was not a good estimate of 3MSE score, but improved the model fit when added to the TICS model. Using estimated 3MSE scores classified more participants with low cognition, and rates of decline were greater than when only the observed 3MSE scores were considered.
3MSE scores can be reliably estimated from the TICS, with or without the IQCODE. Incorporating these estimates captured more cognitive decline in older adults.
评估与改良简易精神状态检查（3MSE）等效的方法，并比较包含和不包含估计分数时3MSE的变化情况。
对心血管健康研究（CHS）中405名年龄≥70岁的参与者子集进行可比性研究，该研究是在美国4个社区开展的一项纵向研究。3MSE、认知状态电话访谈（TICS）和老年人认知衰退知情者问卷（IQCODE）在彼此间隔30天内进行施测。建立回归模型，根据TICS和/或IQCODE预测3MSE分数，并将预测值用于估计4274名CHS参与者纵向随访中缺失的3MSE分数。
TICS解释了3MSE分数变异性的67%，预测分数与观察分数的相关性为0.82。单独使用IQCODE对3MSE分数的估计效果不佳，但加入TICS模型后可改善模型拟合度。使用估计的3MSE分数可将更多认知水平较低的参与者分类，且衰退率高于仅考虑观察到的3MSE分数时的情况。
无论是否使用IQCODE，均可根据TICS可靠地估计3MSE分数。纳入这些估计值能发现老年人更多的认知衰退情况。
