Proctor M E, Turner D W, Kaminski E J, Osetek E M, Heuer M A
Department of Endodontics, Northwestern University.
J Endod. 1991 Jun;17(6):265-70. doi: 10.1016/S0099-2399(06)81864-9.
C-reactive protein (CRP), an acute phase protein synthesized by the liver, increases in serum as much as 3000 times above its normal level in response to acute inflammation. The purpose of this study was to determine whether CRP levels in dental pulps could be correlated with the histological disease status of the pulp and with systemic blood levels of CRP. Inflamed and necrotic pulps were extirpated during routine endodontic therapy. Normal pulps were removed from extracted, intact third molars. One half of each pulp specimen was placed in formalin for histological study; the other half was frozen for immunological study. A serum sample was obtained from each patient at the end of the dental visit. CRP levels were determined by the enzyme-linked immunosorbent assay. Pulps were categorized histologically as normal, inflamed, inflamed/necrotic, or necrotic. The correlation between CRP levels of pulp and serum was not significant. CRP levels of normal pulps differed significantly only from inflamed pulps (p less than 0.05, Dunnett). This increase in CRP appears to be a local phenomenon resulting from the interaction of CRP with various inflammatory mediators in the pulp.
C反应蛋白（CRP）是一种由肝脏合成的急性期蛋白，在急性炎症反应时，血清中CRP水平可升高至正常水平的3000倍。本研究旨在确定牙髓中CRP水平是否与牙髓的组织病理学疾病状态以及全身血液中的CRP水平相关。在常规牙髓治疗过程中摘除发炎和坏死的牙髓。从完整拔除的第三磨牙中获取正常牙髓。每个牙髓标本的一半置于福尔马林中用于组织学研究；另一半冷冻用于免疫学研究。在牙科就诊结束时从每位患者采集一份血清样本。采用酶联免疫吸附测定法测定CRP水平。牙髓在组织学上分为正常、发炎、发炎/坏死或坏死。牙髓和血清中CRP水平之间的相关性不显著。正常牙髓的CRP水平仅与发炎牙髓有显著差异（p<0.05，Dunnett检验）。CRP的这种升高似乎是CRP与牙髓中各种炎症介质相互作用导致的局部现象。
