Rauschenberger C R, Bailey J C, Cootauco C J
J Endod. 1997 Jun;23(6):366-70. doi: 10.1016/S0099-2399(97)80184-7.
Irreversible pulpitis has been associated with an increase in the number of pulpal T-cells. Interleukin-2 (IL-2) stimulates T-cell proliferation and signals the release of other proinflammatory mediators associated with connective tissue degradation. IL-2 has been suggested to be a useful marker of pathologic inflammatory activity in periodontal and systemic disease conditions. The purpose of this study was to analyze normal and inflamed dental pulps for the presence of immunoreactive IL-2 (iIL-2). Normal healthy pulpal tissue was obtained from 17 impacted third molars and inflamed samples were obtained from 12 symptomatic carious molars clinically diagnosed with irreversible pulpitis. Pulpal tissues were collected, prepared, and analyzed for histological status and iIL-2 concentration by a modified ELISA technique. iIL-2 was detected in all vital pulpal tissues. A t-test revealed significant differences in iIL-2 concentrations when inflamed pulpal tissues were compared to normal healthy samples (T = -2.75, p < 0.05). These results suggest that iIL-2 may serve as a marker of pathologic inflammatory activity in irreversible pulpitis.
不可逆性牙髓炎与牙髓T细胞数量增加有关。白细胞介素-2（IL-2）刺激T细胞增殖，并促使释放其他与结缔组织降解相关的促炎介质。IL-2被认为是牙周病和全身性疾病中病理性炎症活动的一个有用标志物。本研究的目的是分析正常和发炎牙髓中免疫反应性IL-2（iIL-2）的存在情况。从17颗阻生第三磨牙获取正常健康的牙髓组织，从12颗临床诊断为不可逆性牙髓炎的有症状龋坏磨牙获取发炎样本。收集牙髓组织，进行制备，并通过改良酶联免疫吸附测定（ELISA）技术分析组织学状态和iIL-2浓度。在所有有活力的牙髓组织中均检测到iIL-2。当将发炎牙髓组织与正常健康样本进行比较时，t检验显示iIL-2浓度存在显著差异（T = -2.75，p < 0.05）。这些结果表明，iIL-2可能作为不可逆性牙髓炎中病理性炎症活动的一个标志物。
