Wang Jinping, Li Haihong, He Qing, Ren Chunghui
Beijing Obstetrics and Gynecology Hospital of Capital Medical University, Beijing 100026, China.
Wei Sheng Yan Jiu. 2009 Mar;38(2):193-5.
To investigate the effect of calcium and vitamin D supplementation during pregnancy, lactation and infants on bone development of infant.
1176 health infants aged 42-365 days and their mothers were recruited as subjects at Pediatric Department in Beijing Obstetrics and Gynecology Hospital during November 2006 to January 2008. Retrospective questionnaire was asked about calcium and vitamin D supplementation during pregnancy, lactation and infant. Blood bone-specific alkaline (BAD) and fontanel anterior (FA) of infant were measured. Chi2 test and logistic regression were used to analyze the research data.
The chi2 test result showed that maternal supplementation with Ca and vitamin D during breastfeeding could decrease infant BAP significantly (P = 0.018), while supplementation during pregnancy could not (P = 0.154). The logistic regression result showed that infant supplementation with Ca and Vitamin D could decrease infant BAP significantly (P = 0.000), while infant feeding methods could not (P > 0.05). The FA size of infants aged < or =42 days had significant negative relationship with BAP (P = 0.017), and no relationship with Ca and vitmin D supplementation during pregnancy.
Supplementation with Ca and vitamin D of mother during lactation and infant could significantly decrease infant BAD. The FA size could not indicate the infant calcium status.
探讨孕期、哺乳期及婴儿期补充钙和维生素D对婴儿骨骼发育的影响。
选取2006年11月至2008年1月在北京妇产医院儿科就诊的1176例42至365日龄健康婴儿及其母亲作为研究对象。采用回顾性问卷调查孕期、哺乳期及婴儿期钙和维生素D的补充情况。测量婴儿血骨特异性碱性磷酸酶（BAD）和前囟（FA）。采用卡方检验和logistic回归分析研究数据。
卡方检验结果显示，母亲在哺乳期补充钙和维生素D可显著降低婴儿BAP（P = 0.018），而孕期补充则无此作用（P = 0.154）。logistic回归结果显示，婴儿补充钙和维生素D可显著降低婴儿BAP（P = 0.000），而婴儿喂养方式则无此作用（P > 0.05）。≤42日龄婴儿的FA大小与BAP呈显著负相关（P = 0.017），与孕期钙和维生素D补充无关。
哺乳期母亲及婴儿补充钙和维生素D可显著降低婴儿BAD。FA大小不能反映婴儿的钙状况。
