Mbou F M, Pagès-Lutz F, Garabédian M, Walrant-Debray O, Leguyader P, Robert P, Pierrisnard E
Service de pédiatrie, centre hospitalier du Lamentin, 97232 Lamentin, Martinique.
J Gynecol Obstet Biol Reprod (Paris). 2009 Apr;38(2):161-7. doi: 10.1016/j.jgyn.2008.03.010. Epub 2008 May 27.
Evaluate vitamin D supplementation and vitamin D status during normal pregnancy in Martinique, a Caribbean region with sufficient sunshine for endogenous vitamin D production all year around; and "to validate" or not the necessity of supplementing pregnant women with vitamin D in Martinique.
A prospective evaluation of their vitamin D status was performed over a winter four-month period on 63 healthy women seen at term delivery. Maternal blood sampling for assays of serum 25 (OH)D, calcium, phosphates and alkaline phosphatase activity was realized in working room. All included women answered a questionnaire allowing to know various parameters known to influence vitamin D and calcium status, as their origin, their food habits, their exposure to sunshine, their supplementation or not with vitamin D during pregnancy.
The sample represented 15% of the pregnant women seen in the department over the study period; 16% of the women had received vitamin D supplementation during pregnancy; at delivery, mean 25-(OH)D serum level in the total cohort was 32.6+/-10.7 ng/ml, with no value below 13 ng/ml; serum calcium and phosphates levels were in the normal range.
These data suggest that, during normal pregnancy, and in the absence of any particular risk factor, systematic vitamin D supplementation is not required in the Martinique region.
评估法属马提尼克岛正常孕期女性的维生素D补充情况及维生素D状态。马提尼克岛位于加勒比地区，全年日照充足，足以进行内源性维生素D合成；并验证或否定在马提尼克岛对孕妇补充维生素D的必要性。
在冬季的四个月期间，对63名足月分娩的健康女性进行了维生素D状态的前瞻性评估。在工作室采集孕妇的血液样本，用于检测血清25（OH）D、钙、磷酸盐和碱性磷酸酶活性。所有纳入的女性都回答了一份问卷，以了解各种已知会影响维生素D和钙状态的参数，如她们的籍贯、饮食习惯、日照情况以及孕期是否补充维生素D。
该样本占研究期间该科室所见孕妇的15%；16%的女性在孕期接受了维生素D补充；分娩时，整个队列的血清25-（OH）D平均水平为32.6±10.7 ng/ml，无低于13 ng/ml的值；血清钙和磷酸盐水平在正常范围内。
这些数据表明，在正常孕期且无任何特殊风险因素的情况下，马提尼克岛地区不需要系统性地补充维生素D。
