α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体亚基也占有一席之地。
AMPA receptor subunits get their share of the pie.
作者信息
Béïque Jean-Claude, Huganir Richard L
机构信息
Heart and Stroke Foundation Centre for Stroke Recovery, Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa K1H8M5, Canada.
出版信息
Neuron. 2009 Apr 30;62(2):165-8. doi: 10.1016/j.neuron.2009.04.016.
Determining the precise subunit composition of AMPARs in situ has been an enduring challenge. In this issue of Neuron, Lu et al. make significant headway into this pesky problem by using a clever single-cell genetic knockout approach. In a Herculean effort, they provide the field with the completeness of a pie chart outlining the contribution of each AMPAR subunit to basal synaptic transmission at CA1 hippocampus synapses--and we get a pie chart for somatic extrasynaptic receptors, too.
确定原位AMPA受体的确切亚基组成一直是一项持久的挑战。在本期《神经元》杂志中，卢等人通过使用巧妙的单细胞基因敲除方法，在这个棘手的问题上取得了重大进展。他们付出了巨大努力，为该领域提供了一个饼状图的完整信息，概述了每个AMPA受体亚基对CA1海马体突触基础突触传递的贡献——而且我们还得到了一个关于体细胞突触外受体的饼状图。
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