在“视觉词形区”中，神经元对整个单词进行高度选择性调谐的证据。
Evidence for highly selective neuronal tuning to whole words in the "visual word form area".
作者信息
Glezer Laurie S, Jiang Xiong, Riesenhuber Maximilian
机构信息
Department of Neuroscience, Georgetown University Medical Center, Research Building Room WP-12, 3970 Reservoir Road NW, Washington, DC 20007, USA.
出版信息
Neuron. 2009 Apr 30;62(2):199-204. doi: 10.1016/j.neuron.2009.03.017.
Abstract
Theories of reading have posited the existence of a neural representation coding for whole real words (i.e., an orthographic lexicon), but experimental support for such a representation has proved elusive. Using fMRI rapid adaptation techniques, we provide evidence that the human left ventral occipitotemporal cortex (specifically the "visual word form area," VWFA) contains a representation based on neurons highly selective for individual real words, in contrast to current theories that posit a sublexical representation in the VWFA.
摘要
阅读理论假定存在一种对整个真实单词进行编码的神经表征（即正字法词汇表），但对这种表征的实验支持却难以获得。利用功能磁共振成像快速适应技术，我们提供了证据表明，人类左腹侧枕颞叶皮层（特别是“视觉词形区”，VWFA）包含一种基于对单个真实单词具有高度选择性的神经元的表征，这与当前认为VWFA中存在亚词汇表征的理论形成对比。
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本文引用的文献
1
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Hum Brain Mapp. 1996;4(4):227-39. doi: 10.1002/(SICI)1097-0193(1996)4:4<227::AID-HBM1>3.0.CO;2-5.
2
Hierarchical coding of letter strings in the ventral stream: dissecting the inner organization of the visual word-form system.腹侧流中字母串的分层编码：剖析视觉词形系统的内部组织
Neuron. 2007 Jul 5;55(1):143-56. doi: 10.1016/j.neuron.2007.05.031.
3
Visual word processing and experiential origins of functional selectivity in human extrastriate cortex.人类纹外皮层功能选择性的视觉词汇加工与经验起源
Proc Natl Acad Sci U S A. 2007 May 22;104(21):9087-92. doi: 10.1073/pnas.0703300104. Epub 2007 May 14.
4
Tuning of the human left fusiform gyrus to sublexical orthographic structure.人类左梭状回对次词汇正字法结构的调谐。
Neuroimage. 2006 Nov 1;33(2):739-48. doi: 10.1016/j.neuroimage.2006.06.053. Epub 2006 Sep 7.
5
The role of the posterior fusiform gyrus in reading.梭状回后部在阅读中的作用。
J Cogn Neurosci. 2006 Jun;18(6):911-22. doi: 10.1162/jocn.2006.18.6.911.
6
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7
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8
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Trends Cogn Sci. 2006 Jan;10(1):14-23. doi: 10.1016/j.tics.2005.11.006.
9
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Behav Res Methods. 2005 Feb;37(1):65-70. doi: 10.3758/bf03206399.
10
The neural code for written words: a proposal.书面文字的神经编码：一项提议。
Trends Cogn Sci. 2005 Jul;9(7):335-41. doi: 10.1016/j.tics.2005.05.004.
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