McMahon J S, Waddell J P, Morton J
Division of Orthopaedic Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.
J Arthroplasty. 1991 Sep;6(3):259-64. doi: 10.1016/s0883-5403(06)80173-7.
One hundred consecutive total hip arthroplasties (THA) were allocated into two groups: 92 patients received 25 mg of indomethacin three times daily for 10 days starting on the first postoperative day; 108 patients received no prophylactic treatment. Clinical examination and radiographs were evaluated by an independent observer at 3, 6, 12, and 24 postoperative months. No difference was noted at the bone-prosthesis interface between the two groups. Short-course indomethacin was felt to deter heterotopic bone formation significantly, while having no deleterious effect on stabilization of the St. Michael's madreporic system. Clinical examination and radiographs were evaluated by an independent observer at 3 and 6 postoperative months; all patients have continued to be observed, with an average follow-up period of 2 years following surgery.
连续100例全髋关节置换术（THA）患者被分为两组：92例患者从术后第一天开始，每天服用25毫克消炎痛，每日三次，共10天；108例患者未接受预防性治疗。由一名独立观察者在术后3、6、12和24个月时对临床检查和X光片进行评估。两组在骨-假体界面处未发现差异。短疗程消炎痛被认为能显著抑制异位骨形成，同时对圣迈克尔多孔系统的稳定性没有有害影响。由一名独立观察者在术后3个月和6个月时对临床检查和X光片进行评估；所有患者均持续接受观察，术后平均随访期为2年。
