Bizzoni Andrea, Lombardi Davide, Maroldi Roberto, Incardona Paolo, Nicolai Piero
Department of Otorhinolaryngology, University of Brescia, Piazza Spedali Civili 1, Brescia, Italy.
Auris Nasus Larynx. 2010 Apr;37(2):233-7. doi: 10.1016/j.anl.2009.03.008. Epub 2009 May 5.
Extramedullary hematopoiesis (EMH) is a systemic reaction to inadequate hematopoiesis. We report two exceedingly rare cases of EMH involving the paranasal sinuses. The first patient, a 30-year-old man, presented with a maxillary sinus mass. The lesion was excised by endoscopic surgery: definitive histology identified foci of EMH within an inflammatory fibromyxoid pseudotumor. The second case occurred in a 29-year-old man affected by intermediate beta-thalassemia. He was hospitalized with a diagnosis of sphenoid sinus mucocele secondary to an ethmoid lesion. The patient underwent endoscopic excision of the mass and drainage of the sphenoid mucocele. At definitive histology, a diagnosis of EMH was established. Herein, the presenting modalities, imaging profile, and treatment options of this rare EMH localization are reviewed.
髓外造血（EMH）是对造血不足的一种全身反应。我们报告两例极为罕见的累及鼻窦的EMH病例。首例患者为一名30岁男性，表现为上颌窦肿物。通过内镜手术切除该病变：最终组织学检查在炎性纤维黏液样假瘤内发现了EMH病灶。第二例发生在一名患有中间型β地中海贫血的29岁男性身上。他因筛窦病变继发蝶窦黏液囊肿而住院。患者接受了肿物的内镜切除及蝶窦黏液囊肿引流术。最终组织学检查确诊为EMH。本文对这种罕见的EMH定位的呈现方式、影像学特征及治疗选择进行了综述。
