Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65201, USA.
Department of Surgery, Columbia, MO 65212, USA.
Int J Mol Sci. 2021 Apr 30;22(9):4802. doi: 10.3390/ijms22094802.
Colorectal cancer (CRC) remains one of the deadliest malignancies worldwide despite recent progress in treatment strategies. Though immune checkpoint inhibition has proven effective for a number of other tumors, it offers benefits in only a small group of CRC patients with high microsatellite instability. In general, heterogenous cell groups in the tumor microenvironment are considered as the major barrier for unveiling the causes of low immune response. Therefore, deconvolution of cellular components in highly heterogeneous microenvironments is crucial for understanding the immune contexture of cancer. In this review, we assimilate current knowledge and recent studies examining anti-tumor immunity in CRC. We also discuss the utilization of novel immune contexture assessment methods that have not been used in CRC research to date.
结直肠癌（CRC）仍然是全球最致命的恶性肿瘤之一，尽管最近在治疗策略方面取得了进展。尽管免疫检查点抑制已被证明对许多其他肿瘤有效，但它仅对少数具有高微卫星不稳定性的 CRC 患者有益。一般来说，肿瘤微环境中的异质细胞群被认为是揭示低免疫反应原因的主要障碍。因此，对高度异质微环境中的细胞成分进行去卷积对于理解癌症的免疫结构至关重要。在这篇综述中，我们综合了目前关于 CRC 中抗肿瘤免疫的知识和最新研究。我们还讨论了利用迄今尚未用于 CRC 研究的新型免疫结构评估方法。
