通过闭环复分解反应制备的联萘基类肽及其抗菌活性。
Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities.
作者信息
Garas Adel, Bremner John B, Coates Jonathan, Deadman John, Keller Paul A, Pyne Stephen G, Rhodes David I
机构信息
School of Chemistry, University of Wollongong, Wollongong, NSW, Australia.
出版信息
Bioorg Med Chem Lett. 2009 Jun 1;19(11):3010-3. doi: 10.1016/j.bmcl.2009.04.046. Epub 2009 Apr 18.
PMID:19409783
Abstract
An efficient synthesis of four new acyclic and four new cyclic binaphthyl-based cationic peptoids is described. These compounds had anti-bacterial activities with MIC values of 4-62 microg/mL against Staphylococcus aureus.
摘要
本文描述了四种新型无环和四种新型基于联萘基的环状阳离子类肽的高效合成方法。这些化合物具有抗菌活性，对金黄色葡萄球菌的最低抑菌浓度（MIC）值为4 - 62微克/毫升。
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