Ando Katsuyuki, Fujita Toshiro
Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.
Free Radic Biol Med. 2009 Aug 1;47(3):213-8. doi: 10.1016/j.freeradbiomed.2009.04.030. Epub 2009 May 3.
Metabolic syndrome is an obesity-associated collection of disorders, each of which contributes to cardiovascular risk. Metabolic syndrome is also associated with overproduction of reactive oxygen species (ROS). ROS contribute to the interrelationship between metabolic syndrome and salt-sensitive hypertension, which are both caused by obesity and excess salt consumption and are major threats to health in developed countries. ROS can induce insulin resistance, which is indispensable for the progression of metabolic syndrome, and salt-sensitive hypertension stimulates ROS production, thereby promoting the development of metabolic syndrome. Moreover, ROS activate mineralocorticoid receptors (MRs) and the sympathetic nervous system, which can contribute to the development of metabolic syndrome and salt-sensitive hypertension. Salt-induced progression of cardiovascular disease (CVD) is also accelerated in animal models with metabolic syndrome, probably owing to further stimulation of ROS overproduction and subsequent ROS-induced MR activation and sympathetic excitation. Therefore, ROS contribute to the progression of the metabolic syndrome itself and to the CVD accompanying it, particularly in conjunction with excessive salt consumption.
代谢综合征是一组与肥胖相关的疾病，其中每种疾病都会增加心血管疾病风险。代谢综合征还与活性氧（ROS）的过度产生有关。ROS导致代谢综合征和盐敏感性高血压之间的相互关系，这两种病症均由肥胖和过量摄入盐分引起，并且是发达国家健康的主要威胁。ROS可诱发胰岛素抵抗，这是代谢综合征进展所必需的，而盐敏感性高血压会刺激ROS的产生，从而促进代谢综合征的发展。此外，ROS激活盐皮质激素受体（MRs）和交感神经系统，这可能会促进代谢综合征和盐敏感性高血压的发展。在患有代谢综合征的动物模型中，盐诱导的心血管疾病（CVD）进展也会加速，这可能是由于ROS过度产生的进一步刺激以及随后ROS诱导的MR激活和交感神经兴奋所致。因此，ROS会导致代谢综合征本身的进展以及伴随的CVD，特别是在过量摄入盐分的情况下。
