炎症性肠病患者的感音神经性听力损失
Sensorineural hearing loss in patients with inflammatory bowel disease.
作者信息
Karmody Collin S, Valdez Tulio A, Desai Urmen, Blevins Nikolas H
机构信息
Department of Otolaryngology, Head and Neck Surgery, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.
出版信息
Am J Otolaryngol. 2009 May-Jun;30(3):166-70. doi: 10.1016/j.amjoto.2008.04.009. Epub 2008 Oct 1.
OBJECTIVE
The study aimed to discuss the association between sensorineural hearing loss (SNHL) and inflammatory bowel disease (IBD).
METHODS
We reviewed cases of patients with known IBD seen in an otolaryngology practice with documentation of all otologic data including age of onset, family history of otologic problems, exposure to noise, audiometric findings, and so on.
RESULTS
Of 38 patients with a history of IBD, 22 had documented SNHL. Nineteen of these had no other identifiable etiology for their inner ear dysfunction. Fourteen of these patients had a diagnosis of ulcerative colitis and 5 had Crohn disease. Sixteen patients had bilateral SNHL, and 3 patients had unilateral SNHL. Only one patient had a lasting response of SNHL to medical treatment.
CONCLUSION
This review suggests that SNHL is an extraintestinal association of IBD. As IBD is considered to be a local or systemic immunopathy, the associated SNHL might also be an expression of systemic immune dysfunction.
目的
本研究旨在探讨感音神经性听力损失（SNHL）与炎症性肠病（IBD）之间的关联。
方法
我们回顾了在耳鼻喉科诊所就诊的已知患有IBD的患者病例，并记录了所有耳科数据，包括发病年龄、耳科问题家族史、噪声暴露、听力测定结果等。
结果
在38例有IBD病史的患者中，22例有记录的SNHL。其中19例内耳功能障碍无其他可识别的病因。这些患者中14例诊断为溃疡性结肠炎，5例为克罗恩病。16例患者为双侧SNHL，3例为单侧SNHL。只有1例患者的SNHL对药物治疗有持久反应。
结论
本综述表明，SNHL是IBD的一种肠外关联。由于IBD被认为是一种局部或全身性免疫病，相关的SNHL也可能是全身免疫功能障碍的一种表现。
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