Pereira Joana B, Junqué Carme, Martí María-Jośe, Ramirez-Ruiz Blanca, Bargalló Nuria, Tolosa Eduardo
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
Mov Disord. 2009 Jun 15;24(8):1193-9. doi: 10.1002/mds.22560.
To determine magnetic resonance imaging patterns of gray matter (GM) atrophy underlying visuospatial and visuoperceptual impairment in Parkinson's disease (PD), we applied voxel-based morphometry to 36 nondemented PD patients and correlated their whole brain GM density with performance on three visuospatial and visuoperceptual tests. In addition, group comparisons between patients and 20 healthy controls were also performed. Correlations between visuospatial performance and GM density were found in the superior parietal lobules and the superior occipital gyrus of PD patients. Poor performance on visuoperceptual tests was also found to be significantly associated with GM decreases in the fusiform, the parahippocampus, and the middle occipital gyrus. Finally, group comparisons between controls and patients showed widespread GM cortical reductions in PD, involving posterior temporal and parietal regions. Taken together, these findings suggest that visuospatial and visuoperceptual dysfunctions reflect structural GM changes in temporo-parietal cortical regions of PD patients.
为了确定帕金森病（PD）中视觉空间和视觉感知障碍背后的灰质（GM）萎缩的磁共振成像模式，我们对36名非痴呆PD患者应用了基于体素的形态学测量方法，并将他们的全脑GM密度与三项视觉空间和视觉感知测试的表现进行关联。此外，还对患者和20名健康对照进行了组间比较。在PD患者的顶上小叶和枕上回中发现了视觉空间表现与GM密度之间的相关性。视觉感知测试表现不佳也被发现与梭状回、海马旁回和枕中回的GM减少显著相关。最后，对照组和患者之间的组间比较显示，PD患者存在广泛的GM皮质减少，涉及颞叶后部和顶叶区域。综上所述，这些发现表明，视觉空间和视觉感知功能障碍反映了PD患者颞顶叶皮质区域的结构性GM变化。
