Allen Naomi E, Roddam Andrew W, Sieri Sabina, Boeing Heiner, Jakobsen Marianne Uhre, Overvad Kim, Tjønneland Anne, Halkjaer Jytte, Vineis Paolo, Contiero Paolo, Palli Domenico, Tumino Rosario, Mattiello Amalia, Kaaks Rudolf, Rohrmann Sabine, Trichopoulou Antonia, Zilis Demosthenes, Koumantaki Yvoni, Peeters Petra H, Bueno-de-Mesquita H Bas, Barricarte Aurelio, Rodríguez Laudina, Dorronsoro Miren, Sánchez Maria-José, Chirlaque María Dolores, Esquius Laura, Manjer Jonas, Wallström Peter, Ljungberg Börje, Hallmans Göran, Bingham Sheila, Khaw Kay-Tee, Boffetta Paolo, Norat Teresa, Mouw Traci, Riboli Elio
Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Int J Cancer. 2009 Aug 15;125(4):982-7. doi: 10.1002/ijc.24447.
Previous case-control studies have suggested that a high intake of animal foods and its associated nutrients are associated with an increased risk of renal cell carcinoma, although data from prospective studies are limited. We report here on the relationship between macronutrient intake and renal cell carcinoma incidence among 435,293 participants enrolled in the European Prospective Investigation into Cancer and Nutrition. Cox proportional hazard models were used to examine the association of dietary intake of fat, protein, carbohydrate, fiber and cholesterol and risk of renal cell carcinoma adjusted for age, sex, center, height, body mass index, physical activity, education, smoking, menopausal status, alcohol and energy intake. During an average 8.8 years of follow-up, 507 renal cell carcinoma cases occurred. Risk of renal cell carcinoma was not associated with macronutrient intake, including nutrients derived from animal sources. Our results indicate that macronutrient intake is not associated with risk of renal cell carcinoma in this cohort of European men and women.
以往的病例对照研究表明，大量摄入动物性食物及其相关营养素与肾细胞癌风险增加有关，尽管前瞻性研究的数据有限。我们在此报告欧洲癌症与营养前瞻性调查中435,293名参与者的宏量营养素摄入量与肾细胞癌发病率之间的关系。采用Cox比例风险模型来检验脂肪、蛋白质、碳水化合物、纤维和胆固醇的饮食摄入量与肾细胞癌风险之间的关联，并对年龄、性别、中心、身高、体重指数、身体活动、教育程度、吸烟、绝经状态、饮酒和能量摄入进行了调整。在平均8.8年的随访期间，共发生了507例肾细胞癌病例。肾细胞癌风险与宏量营养素摄入量无关，包括来自动物性食物的营养素。我们的结果表明，在这组欧洲男性和女性中，宏量营养素摄入量与肾细胞癌风险无关。
