Jeon S R, Eun S H, Shim C S, Ryu C B, Kim J O, Cho J Y, Lee J S, Lee M S, Jin S Y
Digestive Disease Center, Soon Chun Hyang University Hospital, Seoul, Korea.
Endoscopy. 2009 May;41(5):449-56. doi: 10.1055/s-0029-1214607. Epub 2009 May 5.
The aim of this study in canines was to investigate the effectiveness and safety of self-expandable metal stents, which were coated with paclitaxel to minimize the tissue response.
14 dogs (5-10 kg) were randomly allocated to two groups. Drug-eluting stents (DES, n = 7) or nondrug-eluting stents (non-DES, n = 7) were endoscopically inserted and fixed in the esophagus of healthy dogs. Every 2 weeks, for a maximum period of 8 weeks, an endoscopic examination was performed to evaluate the status of stent insertion, the grade of tissue hyperplasia, and mucosal change at both ends of the stent.
One case of stent migration was observed after 4 weeks in the non-DES group. In this group, tissue reaction and hyperplasia remained for more than 4 weeks after stent insertion. By contrast, an endoscopic examination of the surrounding esophageal mucosa in the DES group showed very little tissue reaction, and the stent was easily separated from the esophageal tissue.
Although further studies are required to confirm our results, we suggest that these newly designed DES may provide an alternative tool to manage refractory benign esophageal stricture.
本项针对犬类的研究旨在调查涂有紫杉醇以尽量减少组织反应的自膨式金属支架的有效性和安全性。
将14只体重5 - 10千克的犬随机分为两组。通过内镜将药物洗脱支架（DES，n = 7）或非药物洗脱支架（非DES，n = 7）插入并固定在健康犬的食管中。每2周进行一次内镜检查，最长持续8周，以评估支架植入情况、组织增生程度以及支架两端的黏膜变化。
非DES组在4周后观察到1例支架移位。在该组中，支架植入后组织反应和增生持续超过4周。相比之下，DES组食管周围黏膜的内镜检查显示组织反应非常小，并且支架很容易与食管组织分离。
尽管需要进一步研究来证实我们的结果，但我们认为这些新设计的DES可能为治疗难治性良性食管狭窄提供一种替代工具。
