Focks D A, McLaughlin R E, Linda S B
Medical and Veterinary Entomology Research Laboratory, USDA-ARS, Gainesville, Florida 32604.
J Med Entomol. 1991 Jul;28(4):501-5. doi: 10.1093/jmedent/28.4.501.
Aedes aegypti (L.) females were blood fed a single time on rabbits previously injected subcutaneously with ivermectin at 10 or 50 times the labeled dose recommended for cattle (0.2 mg [AI]/kg body weight). Although adult mosquito survival was unchanged by the low dose, fecundity and hatch were depressed slightly. Females fed on rabbits at the high dose exhibited reduced survival and egg production compared with females fed on control rabbits. Eggs from these females also were less likely to hatch, and subsequent larval survival was lower than controls. The effect of ivermectin on these reproductive parameters diminished as the time between drug administration and blood meal increased.
埃及伊蚊（L.）雌蚊单次吸食预先皮下注射伊维菌素的兔子的血液，伊维菌素的剂量为牛推荐标记剂量（0.2毫克[有效成分]/千克体重）的10倍或50倍。虽然低剂量的伊维菌素对成年蚊子的存活率没有影响，但繁殖力和孵化率略有下降。与吸食对照兔子血液的雌蚊相比，吸食高剂量兔子血液的雌蚊存活率和产卵量降低。这些雌蚊所产的卵孵化的可能性也较小，且随后幼虫的存活率低于对照组。随着给药与吸血之间时间间隔的增加，伊维菌素对这些生殖参数的影响减弱。
