Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds.

作者信息

Nishimura Katsumi, Takenaka Yukiko, Kishi Manami, Tanahashi Takao, Yoshida Hiromi, Okuda Chiaki, Mizushina Yoshiyuki

机构信息

Kobe Pharmaceutical University, Kobe, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2009 May;57(5):476-80. doi: 10.1248/cpb.57.476.

trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta.