Termizy H M, Mafauzy M
Department of Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Malaysia.
Singapore Med J. 2009 Apr;50(4):390-4.
The increased prevalence of metabolic syndrome worldwide is closely related to the rising obesity epidemic. The objectives of the study were to determine the prevalence and identify the associated and prognostic factors that influence the risk of metabolic syndrome among obese patients attending the Obesity Clinic at Hospital Universiti Sains Malaysia.
A study was conducted involving 102 obese persons who attended the Obesity Clinic from January 1 to December 31, 2005. Metabolic syndrome was defined according to the International Diabetes Federation criteria.
The overall prevalence of metabolic syndrome among obese patients was 40.2 percent. The prevalence was higher in females (43.7 percent) than in males (32.3 percent). The prevalence of metabolic syndrome was noted to increase with increasing body mass index class, from class 1 to class 2. However, the prevalence was lower in obesity class 3. The prevalence of metabolic comorbidities of raised blood pressure, reduced high density lipoprotein, high triglyceride and raised fasting blood glucose was 42, 40, 36 and 17 percent, respectively. A quarter of obese patients in this study had no other comorbidity. Based on logistic regression multivariable analysis, age was the only significant associated factor that influenced the risk of having metabolic syndrome.
The prevalence of metabolic syndrome was high and the highest comorbidity was high blood pressure. Age was the only significant risk factor of having this syndrome.
全球代谢综合征患病率的增加与肥胖流行率的上升密切相关。本研究的目的是确定马来西亚理科大学医院肥胖门诊肥胖患者中代谢综合征的患病率,并识别影响其风险的相关因素和预后因素。
对2005年1月1日至12月31日期间到肥胖门诊就诊的102名肥胖者进行了一项研究。代谢综合征根据国际糖尿病联盟标准定义。
肥胖患者中代谢综合征的总体患病率为40.2%。女性患病率(43.7%)高于男性(32.3%)。代谢综合征的患病率随体重指数等级从1级到2级的增加而升高。然而,3级肥胖患者的患病率较低。血压升高、高密度脂蛋白降低、甘油三酯升高和空腹血糖升高的代谢合并症患病率分别为42%、40%、36%和17%。本研究中四分之一的肥胖患者无其他合并症。基于多变量逻辑回归分析,年龄是影响代谢综合征风险的唯一显著相关因素。
代谢综合征患病率较高,最高的合并症是高血压。年龄是患该综合征的唯一显著风险因素。