Panchal Sunil K, Brown Lindsay
Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
J Biomed Biotechnol. 2011;2011:351982. doi: 10.1155/2011/351982. Epub 2010 Dec 30.
Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent.
啮齿动物被广泛用于模拟人类疾病，以增进对疾病症状的病因和进展的了解，并测试潜在的治疗干预措施。肥胖、糖尿病和高血压等慢性疾病统称为代谢综合征，其发病率和死亡率正在不断上升。为了控制这些疾病，在与人类变化密切相似的啮齿动物模型中开展研究至关重要。本综述将考察众多代谢综合征啮齿动物模型在模拟人类疾病病因和进展方面的充分性。主要标准将是啮齿动物模型是否主要通过饮食引发所有症状，尤其是肥胖、糖尿病、高血压以及心脏、血管、肝脏和肾脏功能障碍，因为这些是患有代谢综合征的人类中由饮食诱发的症状。我们得出结论，最接近满足这一标准的模型是高碳水化合物、高脂肪喂养的雄性啮齿动物。
