Del-Rio-Navarro Blanca E, Castro-Rodriguez Jose A, Garibay Nieto Nayely, Berber Arturo, Toussaint Gerogina, Sienra-Monge Juan J, Romieu Isabel
Hospital Infantil de México Federico Gomez, México D.F., México.
J Asthma. 2010 Jun;47(5):501-6. doi: 10.3109/02770901003702808.
The relationship between asthma and obesity has been documented in children and adolescents; however, few studies on metabolic syndrome and asthma have been performed.
To determine the prevalence of metabolic syndrome in adolescents among the following groups: obese with asthma (OA), obese without asthma (ONA), nonobese with asthma (NOA), and nonobese without asthma (NONA).
The authors measured anthropometric (height, weight, waist circumference, body mass index, and waist-hip ratio), clinical (Tanner stage, blood pressure, fat and muscle reserve, and exercise), and biochemical parameters (basal and load glucose, cholesterol, triglycerides, high-density lipoproteins, uric acid, and insulin) in 500 Mexican adolescents.
A total of 111 OA, 198 ONA, 63 NOA, and 71 NONA adolescents completed the study. There were no differences in age, height, Tanner stage, high-density lipoproteins, or basal glucose among groups. Cholesterol, triglycerides, uric acid, basal insulin, and homeostasis model assessment (HOMA)-IR were significantly higher among the obese than nonobese groups but were similar between the OA and ONA groups. The prevalence of impaired fasting glucose was significantly higher among ONA versus OA males. The prevalence of metabolic syndrome (define as > or =3 abnormal cardiometabolic risk factors by de Ferranti, Cook, and International Diabetes Federation [IDF] criteria) was higher among OA teens than in the ONA group; however, this association was significant only among males. Adolescents from the ONA group were able to perform significantly more vigorous exercise than the other groups.
Adolescent males who were obese and also had mild persistent asthma had a significantly higher prevalence of metabolic syndrome than obese males without asthma. However, overall, asthma seems to confer a protective effect against the prediabetes condition in males.
哮喘与肥胖之间的关系在儿童和青少年中已有记录；然而，关于代谢综合征与哮喘的研究却很少。
确定以下几组青少年中代谢综合征的患病率：肥胖合并哮喘（OA）、肥胖不合并哮喘（ONA）、非肥胖合并哮喘（NOA）和非肥胖不合并哮喘（NONA）。
作者对500名墨西哥青少年测量了人体测量学指标（身高、体重、腰围、体重指数和腰臀比）、临床指标（坦纳分期、血压、脂肪和肌肉储备以及运动情况）和生化指标（基础及负荷血糖、胆固醇、甘油三酯、高密度脂蛋白、尿酸和胰岛素）。
共有111名OA、198名ONA、63名NOA和71名NONA青少年完成了研究。各组在年龄、身高、坦纳分期、高密度脂蛋白或基础血糖方面无差异。肥胖组的胆固醇、甘油三酯、尿酸、基础胰岛素和稳态模型评估（HOMA）-IR显著高于非肥胖组，但OA组和ONA组相似。ONA组男性空腹血糖受损的患病率显著高于OA组男性。代谢综合征（根据德费兰蒂、库克和国际糖尿病联盟[IDF]标准定义为≥3项异常心脏代谢危险因素）在OA青少年中的患病率高于ONA组；然而，这种关联仅在男性中显著。ONA组青少年比其他组能够进行更多的剧烈运动。
肥胖且患有轻度持续性哮喘的青少年男性代谢综合征的患病率显著高于无哮喘的肥胖男性。然而，总体而言，哮喘似乎对男性的糖尿病前期状况具有保护作用。
