Coleman Kimberly D, Wright Jacqueline A, Ghosh Mimi, Wira Charles R, Fahey John V
Department of Physiology, Dartmouth Medical School, One Medical Center Drive, Lebanon, New Hampshire.
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Fertil Steril. 2009 Sep;92(3):1107-1109. doi: 10.1016/j.fertnstert.2008.10.047. Epub 2009 May 6.
Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis.
原代人子宫、宫颈和宫颈外基质成纤维细胞组成性分泌肝细胞生长因子(HGF),但只有子宫基质成纤维细胞会在雌激素作用下增加HGF分泌。子宫基质成纤维细胞受雌激素诱导分泌HGF可能对子宫癌和子宫内膜异位症有显著影响。