Department of Gerontology and Geriatrics, Catholic University of Medicine, Rome, Italy.
J Geriatr Psychiatry Neurol. 2009 Dec;22(4):215-22. doi: 10.1177/0891988709335793. Epub 2009 May 7.
The metabolic syndrome (MetS) is being increasingly found in older populations. Depressive symptoms are prevalent in elderly populations, and they are associated with adverse outcomes, chiefly cardiovascular. The aim of this study was to evaluate the association of the 30-item geriatric depression scale (GDS) score with MetS, as defined according to the National Cholesterol Education Program's Adult Treatment Panel III (ATP-III) criteria, in all 353 participants aged 75+ years living in Tuscania (Italy). Metabolic syndrome was associated with the GDS score in a multivariable linear regression analysis in women (beta s= 2.14, 95% CI = 0.14 to 4.14; P = .036), but not in men (beta = -.84, 95% CI = -3.17 to 1.49; P = .476), after adjusting. Analysis of the interaction term confirmed (P = .022) that such an association differed according to sex. Metabolic syndrome is independently associated with depressive symptoms in community-dwelling older women. Older women with depression should be prompted to undergo screening for MetS. Conversely, elderly women with MetS should be assessed for affective disorders.
代谢综合征（MetS）在老年人群中越来越常见。抑郁症状在老年人群中很普遍，与不良结局有关，主要是心血管疾病。本研究旨在评估根据国家胆固醇教育计划成人治疗专家组 III（ATP-III）标准定义的 30 项老年抑郁量表（GDS）评分与代谢综合征在所有 353 名居住在托斯卡纳（意大利）的 75 岁及以上人群中的相关性。在对女性进行多变量线性回归分析时，代谢综合征与 GDS 评分相关（β s= 2.14，95%CI = 0.14 至 4.14；P =.036），但在男性中不相关（β = -.84，95%CI = -3.17 至 1.49；P =.476），调整后。交互项分析证实（P =.022），这种关联因性别而异。代谢综合征与社区居住的老年女性的抑郁症状独立相关。有抑郁症状的老年女性应提示其进行代谢综合征筛查。相反，患有代谢综合征的老年女性应评估其是否存在情感障碍。
