Yu Shasha, Yang Hongmei, Guo Xiaofan, Zheng Liqiang, Sun Yingxian
Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Department of Clinical Epidemiology, Shenjing Hospital of China Medical University, Shenyang, Liaoning, China.
BMC Public Health. 2017 Jan 6;17(1):43. doi: 10.1186/s12889-016-3913-0.
Previous researches aiming to estimate the association between metabolic syndrome and depressive symptoms come out with inconsistent results. Besides, most of them are conducted in the developed areas. There is lack of the data from rural China. The aim of this study is to confirm whether gender difference exists among the relationship between MetS, metabolic components and depressive symptoms in the rural Chinese population.
A cross-sectional analysis enrolled 11430 subjects' aged ≥35 from rural Northeast China. Metabolic and anthropometric indicators were measured according to standard methods. Depressive symptoms were defined using the Patient Health Questionnaire-9 (PHQ-9).
The prevalence of depressive symptoms was 6% among rural Northeast general population and the prevalence of MetS and its components were 39.0% for MetS, 42.9% for abdominal obesity, 67.1% for elevated blood pressure, 47.1% for hyperglycemia, 32.1% for hypertriglyceridemia, 29.5% for low HDL-C. Depressive symptoms were associated with triglyceride component (OR = 1.24, 95%CI: 1.05-1.46, P = 0.01) but not MetS (OR = 1.11, 95%CI: 0.94-1.30, P = 0.23). Moreover, depressive symptoms were associated with triglyceride component (OR = 1.21, 95% CI = 1.00-1.47, P = 0.05) in women only. But once adjusted for menopause status, depressive symptoms were no longer statically associated with triglyceride component (OR = 1.20, 95% CI = 0.99-1.46, P = 0.07).
Depressive symptoms were associated with triglyceride component but not MetS in rural Chinese population. Routine lipid screening should be recommended among rural depressed residents especially among female.
以往旨在评估代谢综合征与抑郁症状之间关联的研究结果并不一致。此外，大多数研究是在发达地区进行的，缺乏来自中国农村的数据。本研究的目的是确认中国农村人群中代谢综合征、代谢组分与抑郁症状之间的关系是否存在性别差异。
一项横断面分析纳入了来自中国东北农村地区11430名年龄≥35岁的受试者。按照标准方法测量代谢指标和人体测量指标。使用患者健康问卷9项（PHQ-9）定义抑郁症状。
中国东北农村普通人群中抑郁症状的患病率为6%，代谢综合征及其组分的患病率分别为：代谢综合征39.0%、腹型肥胖42.9%、血压升高67.1%、高血糖47.1%、高甘油三酯血症32.1%、低高密度脂蛋白胆固醇29.5%。抑郁症状与甘油三酯组分相关（OR = 1.24，95%CI：1.05 - 1.46，P = 0.01），但与代谢综合征无关（OR = 1.11，95%CI：0.94 - 1.30，P = 0.23）。此外，仅在女性中抑郁症状与甘油三酯组分相关（OR = 1.21，95%CI = 1.00 - 1.47，P = 0.05）。但一旦校正绝经状态，抑郁症状与甘油三酯组分不再具有统计学关联（OR = 1.20，95%CI = 0.99 - 1.46，P = 0.07）。
在中国农村人群中，抑郁症状与甘油三酯组分相关，而与代谢综合征无关。建议对农村抑郁居民尤其是女性进行常规血脂筛查。
