College of Arts and Sciences, Roosevelt University, 430 S Michigan Ave., Chicago, IL, 60605, USA.
Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center At Houston, Brownsville, TX, USA.
Qual Life Res. 2020 Aug;29(8):2063-2072. doi: 10.1007/s11136-020-02479-5. Epub 2020 Mar 25.
Results examining associations between metabolic syndrome (MetS) and depression, as well as on quality of life (QoL), are inconsistent. We aimed to determine whether individuals with MetS had decreased mental health-related QoL (MH-QoL) and higher frequency of depressive symptoms.
Data from 1,015 participants from the Fels Longitudinal Study were analyzed (mean age ± SD: 49.6 ± 18.7 years, 29.3% MetS, 51% females). MetS was determined using American Heart Association/National Heart, Lung, and Blood Institute criteria. Depressive symptoms (yes vs. no) were assessed with The Patient Health Questionnaire-9 (PHQ-9). MH-QoL (low (≤ 42) vs. high) was assessed with The Medical Outcomes 36-Item Short Form Survey (SF-36). Sex- and age-stratified mixed effects logistic regressions were used to examine the longitudinal relationship between MetS and MH-QoL while adjusting for covariates such as age, smoking status, and drinking status.
In cross-sectional analysis, MetS was significantly associated with elevated depressive symptoms in women (OR 2.14, 95% CI 1.22-3.78, p < 0.01), but not in men. In the longitudinal analysis, MetS was observed to have a protective effect among men in the older age group as it approached significance (OR 0.34, 95% CI 0.11-1.05, p = 0.06).
MetS was adversely associated with depressive symptoms and poor MH-QoL. Our cross-sectional results suggest that depressive symptoms are higher among women with MetS. Interestingly, our longitudinal results suggest that MH-QoL in men with MetS may improve with age.
关于代谢综合征（MetS）与抑郁之间的关联以及生活质量（QoL）的研究结果并不一致。我们旨在确定患有 MetS 的个体是否心理健康相关 QoL（MH-QoL）降低和抑郁症状发生频率更高。
分析了 Fels 纵向研究的 1015 名参与者的数据（平均年龄±标准差：49.6±18.7 岁，29.3%MetS，51%女性）。MetS 使用美国心脏协会/美国国立心肺血液研究所标准确定。使用 PHQ-9 评估抑郁症状（是/否）。使用 Medical Outcomes 36-Item Short Form Survey（SF-36）评估 MH-QoL（低（≤42）与高）。使用性别和年龄分层混合效应逻辑回归，在调整年龄、吸烟状况和饮酒状况等协变量的情况下，研究 MetS 与 MH-QoL 之间的纵向关系。
在横断面分析中，MetS 与女性的抑郁症状升高显著相关（OR 2.14，95%CI 1.22-3.78，p<0.01），但与男性无关。在纵向分析中，MetS 在年龄较大的男性中观察到具有保护作用，接近显著水平（OR 0.34，95%CI 0.11-1.05，p=0.06）。
MetS 与抑郁症状和较差的 MH-QoL 相关。我们的横断面结果表明，患有 MetS 的女性抑郁症状更高。有趣的是，我们的纵向结果表明，患有 MetS 的男性的 MH-QoL 可能会随着年龄的增长而改善。
