Abd El-Atti Samia, Wasicek Kelley, Mark Scott, Hegazi Refaat
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, and University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
JPEN J Parenter Enteral Nutr. 2009 Sep-Oct;33(5):569-70. doi: 10.1177/0148607109332004. Epub 2009 May 7.
Gastrointestinal disturbances (particularly diarrhea) are often induced in response to cancer treatments such as chemotherapy or radiation. Oral chemotherapeutic agents can induce diarrhea by damaging the intestinal lining. Two common oral drugs used in cancer treatment that are known to have gastrointestinal side effects are capecitabine and lapatinib. In this brief communication, the authors discuss a case study of a stage IV breast cancer patient whose chemotherapy-induced diarrhea was treated successfully with a multispecies combination of probiotics. This is a unique study in which grade 3 chemotherapy-induced diarrhea (characterized by 7-9 stools per day and associated with incontinence and abdominal cramping) was treated with only a multispecies combination of probiotics. Probiotics have been used to treat diarrhea in patients with irritable bowel syndrome, ulcerative colitis, pouchitis, and Crohn's disease. More recently, probiotics have been used to treat chemotherapy-induced diarrhea in colon cancer patients. This case study demonstrates that the probiotics can also be used to treat severe cases of chemotherapy-induced diarrhea in breast cancer patients. The use of different probiotics in gastrointestinal diseases is an increasingly important area of study, and more research into this area is needed. This study demonstrates that probiotics should be considered for advanced breast cancer patients with chemotherapy-induced diarrhea.
胃肠道紊乱（尤其是腹泻）常常是对化疗或放疗等癌症治疗的反应。口服化疗药物可通过损伤肠壁诱发腹泻。已知在癌症治疗中使用的两种常见口服药物卡培他滨和拉帕替尼具有胃肠道副作用。在这篇简短的通讯中，作者讨论了一例IV期乳腺癌患者的病例研究，该患者化疗引起的腹泻通过多种益生菌组合成功治愈。这是一项独特的研究，其中3级化疗引起的腹泻（其特征为每天排便7 - 9次，并伴有大便失禁和腹部绞痛）仅用多种益生菌组合进行治疗。益生菌已被用于治疗肠易激综合征、溃疡性结肠炎、袋炎和克罗恩病患者的腹泻。最近，益生菌已被用于治疗结肠癌患者化疗引起的腹泻。该病例研究表明，益生菌也可用于治疗乳腺癌患者严重的化疗引起的腹泻。在胃肠道疾病中使用不同的益生菌是一个日益重要的研究领域，对此领域需要进行更多研究。这项研究表明，对于患有化疗引起腹泻的晚期乳腺癌患者应考虑使用益生菌。
