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本文引用的文献

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Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells.调节性T细胞对排斥反应的位置和时间依赖性控制最终导致记忆性T细胞生成失败。
J Immunol. 2008 May 15;180(10):6640-8. doi: 10.4049/jimmunol.180.10.6640.
2
Allograft rejection mediated by memory T cells is resistant to regulation.由记忆T细胞介导的同种异体移植排斥反应对调节具有抗性。
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19954-9. doi: 10.1073/pnas.0704397104. Epub 2007 Nov 27.
3
Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help.效应性和记忆性CD8 + T细胞可独立于CD4 + T细胞辅助而针对同种异体抗原产生。
J Immunol. 2006 Feb 15;176(4):2316-23. doi: 10.4049/jimmunol.176.4.2316.
4
Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection.多形核白细胞介导的移植物损伤的抑制与短期共刺激阻断协同作用，以预防心脏同种异体移植排斥反应。
Circulation. 2005 Jul 19;112(3):320-31. doi: 10.1161/CIRCULATIONAHA.104.516708. Epub 2005 Jul 5.
5
Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells.同种异体抗原特异性Foxp3 +调节性T细胞的外周发育需要淋巴结占位。
J Immunol. 2005 Jun 1;174(11):6993-7005. doi: 10.4049/jimmunol.174.11.6993.
6
CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.CD70信号传导对于体内不依赖CD28的CD8 + T细胞介导的同种免疫反应至关重要。
J Immunol. 2005 Feb 1;174(3):1357-64. doi: 10.4049/jimmunol.174.3.1357.
7
4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses.4-1BB和OX40独立发挥作用，以促进强大的CD8和CD4记忆反应。
J Immunol. 2004 Nov 15;173(10):5944-51. doi: 10.4049/jimmunol.173.10.5944.
8
Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis.在同种异体抗原致敏之前发生的T细胞对同种异体移植物的早期反应会上调先天性介导的炎症反应和移植物坏死。
Am J Pathol. 2004 Jul;165(1):147-57. doi: 10.1016/s0002-9440(10)63283-x.
9
In vivo helper functions of alloreactive memory CD4+ T cells remain intact despite donor-specific transfusion and anti-CD40 ligand therapy.尽管进行了供体特异性输血和抗CD40配体治疗，但同种反应性记忆CD4+T细胞的体内辅助功能仍然完好无损。
J Immunol. 2004 May 1;172(9):5456-66. doi: 10.4049/jimmunol.172.9.5456.
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A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo.在体内原发性与继发性CD8 T细胞对流感的反应过程中，共刺激从CD28向4-1BB的转变。
J Immunol. 2004 Jan 15;172(2):981-8. doi: 10.4049/jimmunol.172.2.981.

记忆性T细胞：它们如何破坏耐受性的诱导？

Memory T cells: how might they disrupt the induction of tolerance?

作者信息

Jones Nick D

机构信息

Nuffield Department of Surgery, Transplantation Research Immunology Group, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

出版信息

Transplantation. 2009 May 15;87(9 Suppl):S74-7. doi: 10.1097/TP.0b013e3181a2b83b.

DOI:10.1097/TP.0b013e3181a2b83b
PMID:19424014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2714473/
Abstract

Clinical and experimental evidences suggest that alloreactive memory T cells may be part of the normal T-cell repertoire and that such cells are detrimental to the survival of foreign organ allografts induced by the administration of conventional immunosuppression or experimental tolerance-inducing therapies. The potential mechanisms by which alloreactive memory T cell may form a barrier to the induction of tolerance will be discussed.

摘要

临床和实验证据表明，同种异体反应性记忆T细胞可能是正常T细胞库的一部分，并且这类细胞不利于通过给予传统免疫抑制或实验性诱导耐受疗法所诱导的异体器官移植的存活。本文将讨论同种异体反应性记忆T细胞可能形成耐受诱导障碍的潜在机制。