Matsuzaki M, Shimamoto Y, Tokioka T, Suga K, Sueoka E, Ono K, Sano M, Yamaguchi M
Department of Internal Medicine, Saga Medical School.
Rinsho Ketsueki. 1991 Aug;32(8):874-8.
A 65-year-old man was admitted to our hospital in January 1990, because of weakness of upper limbs. On admission he was found to have generalized lymphadenopathy and leukocytosis. His WBC count was 40,900/microliters with 88% eosinophils. The bone marrow showed an increased number of eosinophils and their precursors but no other abnormalities. A diagnosis of non-Hodgkin's lymphoma (diffuse, medium sized cell type) was made by biopsy of his inguinal lymph node. The result of marker analysis was consistent with CD3+4+8-. The antibody to human T-lymphotropic virus type I was negative. A stomach biopsy revealed lymphoma cell infiltration. Extensive studies to identify the cause of the eosinophilia were undertaken, with consistently negative results. Combination chemotherapy was begun, and resulted in a dramatic resolution of the eosinophilia and the lymphadenopathy. The association of hypereosinophilia with non-Hodgkin's lymphoma is unusual. We report a patient with eosinophilia and non-Hodgkin's lymphoma, and discussed its possible etiology.
一名65岁男性于1990年1月因上肢无力入住我院。入院时发现他有全身淋巴结肿大和白细胞增多。他的白细胞计数为40900/微升，嗜酸性粒细胞占88%。骨髓显示嗜酸性粒细胞及其前体细胞数量增加，但无其他异常。通过腹股沟淋巴结活检诊断为非霍奇金淋巴瘤（弥漫性，中等大小细胞型）。标记分析结果与CD3+4+8-一致。抗人T淋巴细胞白血病病毒I型抗体为阴性。胃活检显示有淋巴瘤细胞浸润。进行了广泛研究以确定嗜酸性粒细胞增多的原因，结果均为阴性。开始联合化疗，嗜酸性粒细胞增多和淋巴结肿大得到显著缓解。嗜酸性粒细胞增多与非霍奇金淋巴瘤的关联并不常见。我们报告了一名患有嗜酸性粒细胞增多和非霍奇金淋巴瘤的患者，并讨论了其可能的病因。
