Lorenzana A N, Schorin M A
Department of Pediatrics, Ochsner Clinic, New Orleans, Louisiana 70121.
Am J Pediatr Hematol Oncol. 1989 Summer;11(2):186-90.
We report a 3 1/2-week-old male infant with Down's syndrome who presented with abdominal distention, ascites, and eosinophilia and was subsequently diagnosed as having an abdominal non-Hodgkin's lymphoma of T-cell type. Because of the unusual association of these two conditions, especially at this early age, the literature was reviewed regarding the possible oncogenic mechanisms in Down's syndrome patients and the various malignancies associated with this condition. Non-Hodgkin's lymphoma is discussed briefly with emphasis on its possible etiologic mechanisms and predisposing conditions, especially the immunodeficiency states. Because this infant presented with non-Hodgkin's lymphoma at an early age, it is considered unlikely that an immunoaberration is responsible. Also, a short discussion of this patient's peripheral and bone marrow eosinophilia is given, implicating a T-cell product (e.g., eosinophil differentiation factor) as the putative pathophysiologic mechanism.
我们报告了一名患有唐氏综合征的3周半大男婴，他出现腹胀、腹水和嗜酸性粒细胞增多，随后被诊断为腹部T细胞型非霍奇金淋巴瘤。鉴于这两种情况的不寻常关联，尤其是在如此小的年龄，我们查阅了关于唐氏综合征患者可能的致癌机制以及与该病症相关的各种恶性肿瘤的文献。本文简要讨论了非霍奇金淋巴瘤，重点是其可能的病因机制和易感条件，尤其是免疫缺陷状态。由于这名婴儿在幼年时就出现了非霍奇金淋巴瘤，因此认为免疫异常不太可能是病因。此外，还对该患者外周血和骨髓嗜酸性粒细胞增多进行了简短讨论，推测一种T细胞产物（如嗜酸性粒细胞分化因子）是可能的病理生理机制。
