Kanaizuka I, Sasaki T, Nakajima H
Department of Dermatology, Yokohama City University School of Medicine.
Nihon Hifuka Gakkai Zasshi. 1991 Jul;101(8):819-23.
Serum type IV collagen 7S and laminin P1 levels were measured with radioimmunoassay in 33 patients with systemic scleroderma (PSS), 6 localized scleroderma (LS), and one mixed connective tissue disease (MCTD). Serum type IV collagen 7S levels were higher in PSS (5.11 +/- 1.11 ng/ml:m +/- SD) and LS (4.68 +/- 0.46 ng/ml) than in normal controls (3.90 +/- 0.85 ng/ml) (p less than 0.001). Serum laminin P1 levels were also significantly higher in PSS (1.75 +/- 0.34 U/ml) and LS (1.38 +/- 0.20 U/ml) compared to the controls (1.19 +/- 0.16 U/ml) (p less than 0.001 and p less than 0.01, respectively). A significant correlation between these two values in PSS was found (r = 0.465, p less than 0.02). These results suggest that the measurements of these values may serve as a marker of PSS.
采用放射免疫分析法对33例系统性硬皮病（PSS）患者、6例局限性硬皮病（LS）患者及1例混合性结缔组织病（MCTD）患者测定血清IV型胶原7S和层粘连蛋白P1水平。PSS组（5.11±1.11 ng/ml：均值±标准差）和LS组（4.68±0.46 ng/ml）血清IV型胶原7S水平高于正常对照组（3.90±0.85 ng/ml）（p＜0.001）。与对照组（1.19±0.16 U/ml）相比，PSS组（1.75±0.34 U/ml）和LS组血清层粘连蛋白P1水平也显著升高（分别为p＜0.001和p＜0.01）。PSS组中这两个值之间存在显著相关性（r = 0.465，p＜0.02）。这些结果表明，这些值的测定可能作为PSS的一个标志物。
