Ono S, Hori M, Yamashita K, Yamakawa M
Department of Dermatology, Nagasaki University School of Medicine.
Nihon Hifuka Gakkai Zasshi. 1991 Aug;101(9):965-71.
A 55 year-old man with a leiomyosarcoma of the rectum and its multiple metastatic lesions in the liver was evaluated for the presence of multiple pigmented macules. The initial lesion was noticed on the face at the age of 53 years old, and then extended to the upper extremities and the back, and became darkened. On physical examination, there were extensive and multiple blue gray macules on the face, upper extremities, shoulders, and the back. Grey flecks on the both palpebral conjunctivas, blue-grey flecks on the palate and blue and brown pigmentation of the gingiva were also noticed. The serum levels of alpha-MSH and growth hormone showed about twice as much as normal range. By light and electron microscopic examinations, pigment bearing cells were identified as dermal melanocytes. From these findings, we diagnosed this case as a generalized type of acquired dermal melanocytosis.
一名55岁男性，患有直肠平滑肌肉瘤并伴有肝脏多处转移灶，因发现多处色素沉着斑而接受评估。最初的病变于53岁时在面部被发现，随后扩展至上肢和背部，并颜色加深。体格检查发现，面部、上肢、肩部和背部有广泛的多发性蓝灰色斑。双侧睑结膜有灰色斑点，腭部有蓝灰色斑点，牙龈有蓝色和棕色色素沉着。α-促黑素和生长激素的血清水平显示约为正常范围的两倍。通过光镜和电镜检查，发现含色素细胞为真皮黑素细胞。根据这些发现，我们将该病例诊断为泛发型获得性皮肤黑素细胞增多症。
